Formulations containing iron-oxide protect skin of colour from effects of visible light

In an interview with Skin Spectrum Weekly, Dr. Pearl Grimes talks about the effects of these formulations on visible light-induced pigmentation.

Iron-oxide-containing formulations have been shown to provide effective protection against pigmentation caused by visible light in Fitzpatrick skin type IV, according to a study. Dr. Pearl Grimes, a dermatologist based in Los Angeles, and an author of the study, evaluated the impact of iron-oxide containing formulations against visible-light-induced skin pigmentation compared to SPF 50 sunscreen and a control. The researchers noted that visible light (400-700nm), contributes to 45% of solar radiation.

The study, which was published in the Journal of Drugs in Dermatology (Jul 1, 2020; 19(7):712-717) found that iron-oxide containing formulations effectively protected against pigmentation caused by visible light as compared to SPF 50 sunscreen and a control. Formulations containing 4.8% iron oxide and 27.25% iron oxide were tested against an SPF that contained titanium and zinc, but no iron oxide.

In an interview with Skin Spectrum Weekly, Dr. Grimes explained that for darker skin types, 15 to 20 minutes of sunlight is enough to trigger hyperpigmentation from visible light. The authors of the study said that the mechanism bywhich metal-oxides work to reduce the effects of visible light is through their ability to absorb, scatter and reflect it.

 “The value of this study is we know that these formulations effectively block out visible light if you use them as camouflage and they also blocked out ultraviolet light as well,” said Dr. Grimes.

“If you look at the spectral absorbance which we have already done, in addition to the clinical findings, the iron oxide formulations have the ability to not only block out visible light, they also blocked out ultraviolet light,” she said.

Dr. Grimes said that her team plans to move forward in generating additional clinical data.

“We want to be able to situate these kinds of formulations and perhaps new formulations in our therapeutic armamentarium [to be able] to manage patients who have pigmentation issues,” she said.

The takeaway: Dr. Grimes said that this proof of concept data now allows her team to advance their research to the randomized clinical trials phase in order to explore the efficacy and how these formulations can be better used in a clinical scenario. 

FROM THE LITERATURE ON SUN PROTECTION FOR SKIN OF COLOUR

The role of sunscreen in melasma and postinflammatory hyperpigmentation

  • Patients with skin of colour are less likely to use sun protection, so conditions such as melasma and postinflammatory hyperpigmentation may be exacerbated in these populations, according to a recent study. In a literary review, researchers recommended broad-spectrum protection including UVA, UVB, and visible light for patients with skin of colour to prevent these conditions.

    From “Indian Journal of Dermatology”

Non-use of sunscreen among adults and the elderly in southern Brazil

  • A recent study found that elderly adults in Brazil tend to not use sunscreen. Researchers recommended prevention strategies and public health policies that promote accessibility of sun protection. 

    From "An Bras Dermatol"

Visible light in photodermatology

  • A recent review of research literature looked at the cutaneous effects of visible light, including the aggravation of hyperpigmentation and melasma in dark-skinned patients.

    From “Photochem Photobiol”

VIDEO: Most know UV protection is important, but still fail to protect themselves


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